Up-to-date Information on
Waldenström’s macroglobulinemia



The state-of-the-art glossary for Waldenström’s macroglobulinemia.

Bruton's tyrosine kinase (BTK)

Bruton's tyrosine kinase (BTK) in the glossary for Waldenström's macroglobulinemia

Is a non-receptor kinase that plays a crucial role in oncogenic signaling that is critical for proliferation and survival of leukemic cells in many B-cell malignancies.

Bruton's tyrosine kinase (BTK), also known as tyrosine-protein kinase BTK, is a non-receptor tyrosine kinase that is encoded by the BTK gene in humans. BTK plays a crucial role in B-cell development as it is required for transmitting signals from the pre-B-cell receptor that forms after successful immunoglobulin heavy chain rearrangement. Ibrutinib, acalabrutinib, and zanubrutinib are approved BTK inhibitors.

Glossary overview