Glossary
The state-of-the-art glossary for Waldenström’s macroglobulinemia.
MAG antibodies
MAG antibodies in the glossary for Waldenström's macroglobulinemia
MAG antibodies (myelin-associated glycoprotein antibodies) – Frequently associated with, and contribute directly to, the pathogenesis of peripheral neuropathies. These autoantibodies frequently occur with IgM paraproteinemia.
Myelin-associated glycoprotein (MAG) is a type of glycoprotein found within the myelin sheath and in Schwann cells, which are responsible for creating and maintaining myelin sheaths on nerve axons. MAG antibodies (myelin-associated glycoprotein antibodies) are frequently associated with, and contribute directly to, the pathogenesis of peripheral neuropathies. In anti-MAG neuropathy the monoclonal gammopathy is IgM. MAG antibodies also frequently occur with IgM paraproteinemia.
Glossary overview