Up-to-date Information on
Waldenström’s macroglobulinemia



The state-of-the-art glossary for Waldenström’s macroglobulinemia.

Glossary for Waldenström's macroglobulinemia


A second generation Bruton's tyrosine kinase inhibitor (BTKi)

Read more: Acalabrutinib


Disease or inflammation involving glandular tissue, especially involving lymph nodes.

Read more: Adenopathy


A family of globular proteins, the most common being the serum albumins.

Read more: Albumin


A lack of sufficient healthy erythrocytes or hemoglobin to carry adequate oxygen to bodily tissues.

Read more: Anemia


B-cells (B-lymphocytes) – A type of leucocyte (white blood cell) of the lymphocyte subtype, which function in the humoral immunity component of the adaptive immune system by secreting antibodies.

Read more: B-cells


An alkylating agent (chemotherapy)

Read more: Bendamustine


Bortezomib is a proteosome inhibitor.

Read more: Bortezomib

Bruton's tyrosine kinase (BTK)

Is a non-receptor kinase that plays a crucial role in oncogenic signaling that is critical for proliferation and survival of leukemic cells in many B-cell malignancies.

Read more: Bruton's tyrosine kinase (BTK)


An antigen expressed on the surface of B-cells

Read more: CD20

Cold agglutinin disease (CAD)

A rare hematological condition in which the immune system destroys erythrocytes.

Read more: Cold agglutinin disease (CAD)


The presence of one or more additional conditions co-occurring with a primary condition.

Read more: Comorbidities

Constitutional symptoms

A group of nonspecific symptoms (such as appetite loss, weight loss, headache and fevers) that can affect several different bodily systems.

Read more: Constitutional symptoms


In cryoglobulinemia, abnormal blood proteins called cryoglobulins clump together at cold temperatures.

Read more: Cryoglobulinemia


CT (computerized tomography) scan – A medical imaging technique which utilizes computer-processed combinations of multiple X-ray measurements taken from different angles to produce tomographic images of the body.

Read more: CT


An immunosuppressive alkylating agent (chemotherapy).

Read more: Cyclophosphamide


Reduced number of mature blood cells.

Read more: Cytopenia


Dexamethasone is a glucocorticoid medication.

Read more: Dexamethasone


The most common type of heart arrhythmia (irregular heartbeat) that can interrupt normal blood flow.

Read more: Fibrillation


Hepatomegaly is abnormal enlargement of the liver.

Read more: Hepatomegaly


High blood pressure.

Read more: Hypertension


Increased blood viscosity, leading to reduced blood flow.

Read more: Hyperviscosity


A small molecule inhibitor of Bruton's tyrosine kinase

Read more: Ibrutinib


The largest of several types of immunoglobulin (antibody) produced by vertebrates. The first antibody produced in response to initial antigen exposure.

Read more: IgM


The treatment and management of disease by combining immunotherapy with chemotherapy

Read more: Immunochemotherapy


LDH (lactate dehydrogenase), an enzyme found in nearly all living cells. LDH catalyzes the reversible conversion of lactate to pyruvate.

Read more: LDH


Lymphadenopathy or adenopathy is a disease of the lymph nodes, in which they are abnormal in size or consistency.

Read more: Lymphadenopathy


An abnormal antibody (immunoglobulin) or fragment thereof, produced in excess by abnormal monoclonal proliferation of plasma cells.

Read more: M-protein

MAG antibodies

MAG antibodies (myelin-associated glycoprotein antibodies) – Frequently associated with, and contribute directly to, the pathogenesis of peripheral neuropathies. These autoantibodies frequently occur with IgM paraproteinemia.

Read more: MAG antibodies


MYD88 (myeloid differentiation factor 88) is a driver gene found in hematologic B-cell malignancies.

Read more: MYD88


Disease or dysfunction of one or more nerves, typically causing pain, numbness or weakness.

Read more: Neuropathy

Nucleoside analogues

Synthetic, chemically modified nucleosides that mimic their physiological counterparts (endogenous nucleosides) and block cellular division or viral replication by impairing DNA/RNA synthesis or by inhibition of cellular or viral enzymes involved in nucleoside/tide metabolism.

Read more: Nucleoside analogues


An abnormal protein produced by plasma cells in the bone marrow

Read more: Paraprotein


PCR (polymerase chain reaction) – A technology used to amplify fragments of DNA exponentially.

Read more: PCR

PET imaging

PET imaging (positron emission tomography) – A functional imaging technique which utilizes radiotracers (radioactive substances) used to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption.

Read more: PET imaging


The branch of pharmacology concerned with the movement of drugs within the body.

Read more: Pharmacokinetics

Plasma cells

White blood cells that originate in the bone marrow and secrete large quantities of antibodies in response to antigen presentation

Read more: Plasma cells


The removal, treatment, and return or exchange of blood plasma or plasma components from and to the blood circulation

Read more: Plasmapheresis

Proteasome inhibitors

Drugs that block the action of proteasomes (cellular complexes that break down proteins)

Read more: Proteasome inhibitors


Rituximab is a chimeric monoclonal antibody anti-CD20 antibody

Read more: Rituximab


SFLC (serum-free light chain) – Proteins produced by plasma cells, which link together with other proteins (heavy chains) to form immunoglobulins (antibodies) that target and neutralize specific infectious agents such as bacteria and viruses

Read more: SFLC


Splenomegaly is an enlargement of the spleen.

Read more: Splenomegaly


A second generation small molecule inhibitor of Bruton's tyrosine kinase

Read more: Tirabrutinib


A small molecule BCL2 inhibitor

Read more: Venetoclax


A small molecule second-generation inhibitor of Bruton's tyrosine kinase

Read more: Zanubrutinib

𝛃2 microglobulin

Beta-2-microglobulin is a small membrane protein associated with the heavy chains of class I major histocompatibility complex (MHC) proteins and is, therefore, on the surface of all nucleated cells (excludes red blood cells).

Read more: 𝛃2 microglobulin